The advent of nanotechnology and artificial intelligence (AI) has revolutionized the field of drug delivery, leading to the development of smart nanocarriers that can precisely target diseased tissues while minimizing off-target effects. These nanocarriers, often composed of biocompatible and biodegradable materials, are engineered to respond to specific stimuli such as pH, temperature, or enzymatic activity, enabling controlled release of therapeutic agents. The integration of AI into the design and optimization of these nanocarriers has further enhanced their efficacy, allowing for personalized medicine approaches that consider individual patient variability. This article provides a comprehensive review of the materials and methods used in the fabrication of smart nanocarriers, the role of AI in their development, and the results of recent studies demonstrating their potential in targeted drug delivery. The discussion highlights the challenges and future directions in this rapidly evolving field, concluding with the potential impact of these technologies on healthcare.